SkyWest has 15 domiciles scattered throughout the United States.

EMB

Salt Lake City, Utah
Portland, Oregon
Fresno, California
Palm Springs, California
San Diego, California
Monterey, California
San Diego, California
San Luis Obispo, California
Sacramento, California
Santa Barbara, California
San Francisco, California (reserve base)
Los Angeles, California (reserve base)

CRJ

Denver, Colorado
Colorado Springs, Colorado
Fresno, California
Palm Springs, California
Sacramento, California
Los Angeles (reserve base)
San Francisco (reserve base)
Salt Lake City, Utah
Santa Barbara, California
Tucson, Arizona
Chicago, Illinois
Milwaukee, Wisconsin
Atlanta, Georgia